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Bird flu could take 142m lives says study { February 16 2006 }

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   http://www.cnn.com/2006/HEALTH/conditions/02/15/birdflu.cost/index.html

http://www.cnn.com/2006/HEALTH/conditions/02/15/birdflu.cost/index.html

Bird flu 'could take 142m lives'
Worst case economic cost is $4.4 trillion

Thursday, February 16, 2006; Posted: 10:28 a.m. EST (15:28 GMT)

SYDNEY, Australia (CNN) -- As many as 142 million people around the world could die if bird flu turns into a "worst case" influenza pandemic, according to a sobering new study of its possible consequences.

And global economic losses could run to $4.4 trillion -- the equivalent of wiping out the Japanese economy's annual output.

The study, prepared for the Sydney, Australia-based Lowy Institute think tank, says there are "enormous uncertainties" about whether a flu pandemic might happen, and where and when it might happen first.

But it says even a mild pandemic could kill 1.4 million people and cost $330 billion.

In its "ultra" or worst-case scenario, Hong Kong's economy is halved, the large-scale collapse of Asian economic activity causes global trade flows to dry up, and money flows out to safe havens in North America and Europe. Deaths could top 28 million in China and 24 million in India.

The report's release in Sydney Thursday comes as two more countries in Europe -- Germany and Austria -- report that the deadly H5N1 bird flu virus has been detected in wild fowl (Full story).

The Lowy Institute's report, titled Global Macroeconomic Consequences of Pandemic Influenza, looks at four possible scenarios:


* Mild, in which the pandemic is similar to the 1968-69 Hong Kong flu;


* Moderate, similar to the 1957 Asian flu;


* Severe, similar to the 1918-19 Spanish flu (which infected an estimated 1 billion people and claimed as many as 50 million lives);


* An "ultra" scenario that is worse than the Spanish flu outbreak.

Although the 1918-19 flu outbreak probably originated in Asia, it was known as the Spanish flu because the Spanish media were the first to report on its impact.

Since bird flu first appeared in China's Guangdong province -- which adjoins Hong Kong -- in 1996, the disease has claimed more than 90 human lives -- almost all in Asia, with the most recent deaths in Turkey.

In addition, about 200 million birds around the world have died or been culled.

Outside of Asia, there have been bird flu outbreaks in Greece, Italy, Turkey, Croatia, Russia, Azerbaijan and Romania in Europe, Iraq and Iran in the Middle East and in Nigeria, Africa. (Full story)

This spread of the disease from Asia to the fringes of Europe in recent weeks has prompted massive global attention on possible prevention measures, with the U.S., the EU and countries such as China and Japan committing hefty financial and human resources to combating the disease.

But the new Lowy Institute report, by the Australian National University's Prof. Warwick McKibbin and research fellow Dr Alexandra Sidorenko, says the major difficulty with influenza vaccine development is "the need to hit the constantly moving target as the virus mutates very rapidly."

Their observation follows a scientific study released last week which said bird flu was much more diverse than previously thought, with at least four distinct types of the deadly H5N1 virus (Full story).

In that study, a group of 29 scientists around the globe found that the virus was both more genetically diverse and able to survive in birds showing no signs of illness.

One of the researchers, Dr. Malik Peiris, professor of microbiology at Hong Kong University, told CNN on February 8 that regional virus types meant there was a need to look for "broad cross-protection" rather than a single vaccine.

Peiris said that while wild birds may contribute to the introduction and spread of bird flu, the perpetuation of the disease was through stocks of domestic poultry. He said no country was fully prepared to combat the disease, which needed to be tracked back and tackled at its source.

Further mutation
So far, all but a handful of cases of human sickness have been caused by direct contact with sick birds, suggesting the virus is unable to move easily among humans.

But health officials have warned that with continued exposure to people, the virus could mutate further and develop that ability.

While scientists scramble to prepare an effective medical response, the Lowy Institute report primarily looks at the macroeconomic impact of a flu pandemic.

It said there would be four main sets of "shocks" for each scenario: shocks to the labor force (through deaths and dislocation to production); additional supply shocks through increased costs; demand shocks; and risk premium shocks, involving financial flows.

In the worst scenario, it said the death toll could reach 28.4 million in China, 24 million in India, 11.4 million in Indonesia, 4.1 million in the Philippines, 2.1 million in Japan, 2.0 million in the United States and 5.6 million in Europe. In the world's least developed countries, the toll could top 33 million.

The study's figure of 142 million possible deaths is similar to an earlier estimate of 150 million deaths by World Health Organization senior official David Nabarro, when he was named as head of the United Nations avian flu response team in September last year.

The Lowy Institute study found that East Asian economies would be proportionately more affected than the United States or Europe. In the "ultra" or worst-case scenario, Hong Kong's economy, for example, would shrink by more than 53 percent.

"This is clearly a major economic catastrophe," the report's authors note.

"The large scale collapse of Asia causes global trade flows to dry up and capital to flow to safe havens in North America and Europe."

Japan would experience a larger shock than other industrialized economies, but a smaller shock than the rest of East Asia. However, its integration with the collapsing East Asian economies means it would take a further shock through declining trade flows.

The authors say a "key part of the story" is the monetary policy response.

"Those countries that tend to focus on preventing exchange rate changes are coincidentally the countries that experience the largest epidemiological shocks," they say.

"This is particularly true of Hong Kong, which receives the largest shocks and has the most rigid exchange rate regime."

The report concludes that a "large investment of resources" should be dedicated to preventing an outbreak of pandemic influenza.

The Lowy Institute report is authored by Prof. Warwick McKibbin, professorial fellow at the institute and Professor of Economics at the Australian National University (ANU); and Dr Alexandra Sidorenko, a research fellow at the ANU's National Center for Epidemiology and Population Health, and adjunct research fellow at the ANU's Australian Center for Economic Research on Health.

CNN's Geoff Hiscock in Sydney contributed to this report

Copyright 2006 CNN. All rights reserved.This material may not be published, broadcast, rewritten, or redistributed. Associated Press contributed to this report.




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